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The second is more interesting, because it is a case where the half-life is genuinely misleading on its own — blood levels stayed above the compound's mouse NNMT IC50 of 78 ng/mL for only about 2 to 4 hours after injection, so a 13-hour terminal half-life describes how long a decaying tail remains detectable, not how long the enzyme is actually inhibited

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It increased in the first days, while subsequently decreasing in later days